Description

4,6-Difluoropyridin-3-Ol is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which enables precise molecular modifications essential for developing novel active compounds. This intermediate is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams focused on creating new fluorinated molecules with enhanced biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of new-generation herbicides and fungicides, where the difluoropyridine moiety can improve metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other advanced functional materials.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring specific fluorination patterns.

Basic Information

Product Name	4,6-Difluoropyridin-3-Ol
CAS No.	1227597-52-5
Molecular Formula	C5H3F2NO
Molecular Weight	131.08 g/mol
Synonyms	3-Hydroxy-4,6-difluoropyridine; 4,6-Difluoro-3-hydroxypyridine; 4,6-Difluoropyridin-3-ol; 4,6-Difluoro-3-pyridinol; 3-Pyridinol, 4,6-difluoro-; 1227597-52-5
EINECS	Contact for details

Quality Control

Our 4,6-Difluoropyridin-3-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.