Description

2-Fluoro-4-Hydroxy-3-Methylpyridine is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. This compound matters for its role as a crucial intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and hydroxyl functionalities into complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects requiring specific fluoropyridine scaffolds.

Basic Information

Product Name	2-Fluoro-4-Hydroxy-3-Methylpyridine
CAS No.	1227593-90-9
Molecular Formula	C6H6FNO
Molecular Weight	127.12 g/mol
Synonyms	3-Methyl-2-fluoro-4-pyridinol; 4-Hydroxy-3-methyl-2-fluoropyridine; 2-Fluoro-3-methyl-4-pyridinol; 2-Fluoro-4-pyridinol, 3-methyl-; 2-Fluoro-4-hydroxy-3-methylpyridine; 2-Fluoro-3-methylpyridin-4-ol
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxy-3-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed batch-specific data are available upon request. We support compliance with relevant guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.