Description

2,6-Difluoropyridine-4-Carboxaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring two fluorine atoms and an aldehyde group, makes it an essential precursor for creating complex molecules with tailored properties. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Used to create sophisticated ligands for transition metal catalysis and organocatalysts for asymmetric synthesis.
• Material Science Research: Intermediate in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Fluorinated Compound Library: Essential starting material for generating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Cross-Coupling Reactions: The aldehyde and halogenated pyridine structure makes it suitable for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Product Name	2,6-Difluoropyridine-4-Carboxaldehyde
CAS No.	1227588-39-7
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	4-Formyl-2,6-difluoropyridine; 2,6-Difluoro-4-pyridinecarboxaldehyde; 2,6-Difluoropyridine-4-carbaldehyde; 2,6-Difluoroisonicotinaldehyde; 4-Pyridinecarboxaldehyde, 2,6-difluoro-; 2,6-Difluoro-4-formylpyridine
EINECS	Contact for details

Quality Control

Our 2,6-Difluoropyridine-4-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.