Description

3,6-Difluoropicolinaldehyde is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value proposition lies in the strategic placement of fluorine atoms and an aldehyde functional group on the pyridine ring, making it a versatile precursor for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, leveraging the fluorine atoms to enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate and tridentate ligands used in homogeneous catalysis and material science.
• Fluorinated Heterocycle Library Construction: Essential for combinatorial and medicinal chemistry programs aimed at expanding chemical space with fluorinated picolinaldehyde derivatives.
• Organic Electronic Materials: Investigated as a starting material for the synthesis of fluorinated organic semiconductors and light-emitting materials.

Basic Information

Product Name	3,6-Difluoropicolinaldehyde
CAS No.	1227583-74-5
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	2,5-Difluoropyridine-4-carboxaldehyde; 3,6-Difluoro-4-pyridinecarboxaldehyde; 4-Pyridinecarboxaldehyde, 3,6-difluoro-; Picolinaldehyde, 3,6-difluoro-; 3,6-Difluoropyridine-4-carbaldehyde; 3,6-Difluoroisonicotinaldehyde
EINECS	Contact for details

Quality Control

Our 3,6-Difluoropicolinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is easily oxidized (store under inert atmosphere). Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.