Description

5,6-Difluoronicotinaldehyde is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate and versatile chemical building block. Its unique difluoro-substituted nicotinaldehyde structure provides a reactive aldehyde group and a halogenated heterocyclic core, enabling precise synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and fluorinated polymers.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Cross-Coupling Reactions: The aldehyde and halogenated ring make it a valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	5,6-Difluoronicotinaldehyde
CAS No.	1227583-68-7
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	5,6-Difluoropyridine-3-carboxaldehyde; 3-Pyridinecarboxaldehyde, 5,6-difluoro-; 5,6-Difluoro-3-formylpyridine; 5,6-Difluoronicotinaldehyde; Difluoronicotinaldehyde; 1227583-68-7; 5,6-Difluoronicotinyl aldehyde
EINECS	Contact for details

Quality Control

Our 5,6-Difluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory and manufacturing practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.