Description

3-Chloro-5-Fluoropyridin-4-Amine is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated amine functionality into heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in kinase inhibitor and central nervous system (CNS) active molecule research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides that require halogenated pyridine cores.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and functional dyes where fluorinated amines modify electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic and Industrial R&D: Utilized in research laboratories for methodological studies and exploring new chemical reactions involving halogenated heterocycles.

Basic Information

Product Name	3-Chloro-5-Fluoropyridin-4-Amine
CAS No.	1227581-38-5
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	4-Amino-3-chloro-5-fluoropyridine; 3-Chloro-5-fluoro-4-pyridinamine; 5-Fluoro-3-chloropyridin-4-amine; 4-Pyridinamine, 3-chloro-5-fluoro-; 3-Chloro-5-fluoropyridin-4-ylamine; 3-Chloro-5-fluoro-4-aminopyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoropyridin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.