Description

2-Hydroxy-6-(Trifluoromethyl)Isonicotinic Acid is a high-value, multi-functional heterocyclic building block characterized by its trifluoromethyl and carboxylic acid functional groups. This compound is essential for medicinal chemistry and agrochemical research, where its unique structure enables the fine-tuning of molecular properties such as lipophilicity, metabolic stability, and binding affinity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized chelating ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services under cGMP or ISO standards.

Basic Information

Product Name	2-Hydroxy-6-(Trifluoromethyl)Isonicotinic Acid
CAS No.	1227580-92-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	6-(Trifluoromethyl)-2-hydroxypyridine-4-carboxylic acid; 2-Hydroxy-6-trifluoromethyl-isonicotinic acid; 4-Pyridinecarboxylic acid, 2-hydroxy-6-(trifluoromethyl)-; 2-Hydroxy-6-(trifluoromethyl)pyridine-4-carboxylic acid; 6-(Trifluoromethyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid; 2-Hydroxy-6-trifluoromethylnicotinic acid; 2-Hydroxy-6-(trifluoromethyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-(Trifluoromethyl)Isonicotinic Acid is manufactured under a strict quality management system. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements of research and development. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.