Description

2-Fluoro-6-(Trifluoromethyl)Isonicotinic Acid is a high-value fluorinated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart desirable properties like enhanced metabolic stability and lipophilicity to final compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other functional materials.
• Chemical Biology Probes: Utilized to construct molecular probes for studying enzyme function and biological pathways due to its bioisosteric properties.

Basic Information

Product Name	2-Fluoro-6-(Trifluoromethyl)Isonicotinic Acid
CAS No.	1227579-85-2
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-fluoro-6-(trifluoromethyl)-; 2-Fluoro-6-trifluoromethylisonicotinic acid; 6-Trifluoromethyl-2-fluoroisonicotinic acid; 2-Fluoro-6-(trifluoromethyl)-4-pyridinecarboxylic acid; FTIPA; Isonicotinic acid, 2-fluoro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(Trifluoromethyl)Isonicotinic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.