Description

2,3-Difluoro-4-(Hydroxymethyl)Pyridine is a high-value, multi-functional pyridine derivative characterized by its difluoro substitution and hydroxymethyl side chain. This unique molecular structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for complex organic synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-infectives.
• Agrochemical Synthesis: Used as a building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: The pyridine core and functional groups make it suitable for creating novel ligands for metal catalysis and organocatalysts.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials due to its aromatic fluorine chemistry.
• Chemical Biology & Proteomics: Serves as a valuable scaffold for designing molecular probes, enzyme inhibitors, and bio-conjugation linkers.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	2,3-Difluoro-4-(Hydroxymethyl)Pyridine
CAS No.	1227579-07-8
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	4-(Hydroxymethyl)-2,3-difluoropyridine; 2,3-Difluoropyridine-4-methanol; (2,3-Difluoropyridin-4-yl)methanol; 2,3-Difluoro-4-pyridinemethanol; 2,3-Difluoro-4-(hydroxymethyl)pyridine; Difluorohydroxymethylpyridine; Pyridine, 2,3-difluoro-4-(hydroxymethyl)-
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(Hydroxymethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring cGMP, ISO 9001, and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.