Description

2-Chloro-4-Fluoropyridin-3-Ol is a high-purity fluorinated pyridine derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its unique halogenated structure, which enables precise molecular modifications essential for developing advanced materials and active pharmaceutical ingredients. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand & Catalyst Precursor: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-4-Fluoropyridin-3-Ol
CAS No.	1227577-96-9
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	3-Hydroxy-2-chloro-4-fluoropyridine; 2-Chloro-4-fluoro-3-hydroxypyridine; 2-Chloro-4-fluoropyridin-3-ol; 4-Fluoro-2-chloro-3-pyridinol; 3-Pyridinol, 2-chloro-4-fluoro-; 1227577-96-9; 2-Chloro-4-fluoro-3-pyridinol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoropyridin-3-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, batch-to-batch consistency, and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to the compound's sensitivity to light and potential moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.