Description

Ethyl 2-Fluoro-5-(Trifluoromethyl)Nicotinate is a high-value fluorinated nicotinate derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethyl groups, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine motifs contribute to efficacy and environmental profile.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated ligands, liquid crystals, and functional polymers.
• Chemical Biology Probe Development: Employed in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring fluorinated pyridine scaffolds.

Basic Information

Product Name	Ethyl 2-Fluoro-5-(Trifluoromethyl)Nicotinate
CAS No.	1227576-19-3
Molecular Formula	C9H7F4NO2
Molecular Weight	237.15 g/mol
Synonyms	2-Fluoro-5-(trifluoromethyl)nicotinic acid ethyl ester; Ethyl 2-fluoro-5-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-fluoro-5-(trifluoromethyl)-, ethyl ester; 1227576-19-3; Ethyl 2-fluoro-5-trifluoromethylnicotinate; 2-Fluoro-5-trifluoromethyl-nicotinic acid ethyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated intermediates. Every batch of Ethyl 2-Fluoro-5-(Trifluoromethyl)Nicotinate is analyzed to ensure high chemical purity and consistency, supported by a comprehensive Certificate of Analysis (COA). Our quality management system is designed to meet the exacting standards of pharmaceutical and agrochemical R&D, ensuring reliable supply and batch-to-batch reproducibility for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.