Description

3-Fluoro-2-(trifluoromethyl)isonicotinaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used to develop new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-based properties.
• Chemical Research: Versatile reagent for introducing the 3-fluoro-2-(trifluoromethyl)pyridine moiety into complex molecular architectures in medicinal and process chemistry.
• Fluorine Chemistry: Valuable substrate for studying structure-activity relationships (SAR) and for the development of new fluorination methodologies.

Basic Information

Product Name	3-Fluoro-2-(trifluoromethyl)isonicotinaldehyde
CAS No.	1227574-90-4
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 3-fluoro-2-(trifluoromethyl)-; 3-Fluoro-2-trifluoromethylisonicotinaldehyde; 3-Fluoro-2-(trifluoromethyl)-4-pyridinecarboxaldehyde; 2-(Trifluoromethyl)-3-fluoropyridine-4-carbaldehyde; 3-Fluoro-2-(trifluoromethyl)isonicotinic aldehyde; 1227574-90-4; 3-Fluoro-2-trifluoromethyl-4-pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-(trifluoromethyl)isonicotinaldehyde is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with cGMP principles where applicable, supporting your regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.