Description

2-Fluoro-4-Methylpyridine-3-Methanol is a high-purity fluorinated pyridine derivative, a versatile and valuable building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and a hydroxymethyl group, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms into complex molecules to modulate their biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology, central nervous system (CNS), and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where fluorination enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other advanced functional materials.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of biomolecules for metabolic pathway studies and imaging applications.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring precise fluorination at the pyridine core.

Basic Information

Product Name	2-Fluoro-4-Methylpyridine-3-Methanol
CAS No.	1227574-63-1
Molecular Formula	C7H8FNO
Molecular Weight	141.14 g/mol
Synonyms	(3-Hydroxymethyl-4-methyl-2-pyridyl)fluoride; 2-Fluoro-4-methyl-3-pyridinemethanol; 3-(Hydroxymethyl)-2-fluoro-4-methylpyridine; 2-Fluoro-4-methyl-3-pyridylmethanol; 2-Fluoro-4-methylpyridine-3-ylmethanol; 4-Methyl-2-fluoro-3-pyridinemethanol
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Methylpyridine-3-Methanol is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.