Description

3-Chloro-2-Chloromethyl-6-(Trifluoromethyl)Pyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both chloro and chloromethyl substituents alongside a trifluoromethyl group, makes it an exceptionally versatile building block for constructing complex molecules. This compound is essential for research and development chemists and process engineers in the agrochemical and pharmaceutical industries, where it is used to introduce key structural motifs that enhance the biological activity and physical properties of final products.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel insecticides, herbicides, and fungicides, where the pyridine core and halogenated side chains contribute to target specificity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in creating molecules with improved metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a starting material for the preparation of specialized ligands used in catalysis and material science.
• Functional Material Research: Employed in the development of advanced organic materials, including liquid crystals and electronic chemicals, due to its electron-withdrawing characteristics.
• Custom Synthesis & Scale-Up: Provides a reliable and scalable intermediate for contract research organizations (CROs) and custom synthesis partners working on proprietary compounds.

Basic Information

Product Name	3-Chloro-2-Chloromethyl-6-(Trifluoromethyl)Pyridine
CAS No.	1227574-28-8
Molecular Formula	C7H4Cl2F3N
Molecular Weight	230.02 g/mol
Synonyms	2-(Chloromethyl)-3-chloro-6-(trifluoromethyl)pyridine; 3-Chloro-2-chloromethyl-6-trifluoromethylpyridine; 6-(Trifluoromethyl)-3-chloro-2-pyridinemethanol, chloromethyl ether; 2-Chloromethyl-3-chloro-6-trifluoromethylpyridine; Pyridine, 3-chloro-2-(chloromethyl)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Chloromethyl-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of related substances. A comprehensive Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and impurity profiles. We support custom synthesis and can tailor specifications, including higher purity grades (≥98%, ≥99%), to meet specific project requirements under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.