Description

3-Bromo-5-Fluoroisonicotinaldehyde is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both bromo and fluoro substituents on the aldehyde-bearing pyridine ring, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to create advanced herbicides and pesticides, leveraging the bioactivity of the halogenated pyridine scaffold.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce complex substituents.
• Derivatization for Library Synthesis: The reactive aldehyde group allows for facile condensation reactions, enabling the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	3-Bromo-5-Fluoroisonicotinaldehyde
CAS No.	1227573-02-5
Molecular Formula	C6H3BrFNO
Molecular Weight	203.99 g/mol
Synonyms	3-Bromo-5-fluoropyridine-4-carbaldehyde; 5-Fluoro-3-bromoisonicotinaldehyde; 4-Pyridinecarboxaldehyde, 3-bromo-5-fluoro-; 3-Bromo-5-fluoro-4-formylpyridine; 3-Bromo-5-fluoropyridine-4-carboxaldehyde; 1227573-02-5 (CAS); 3-Br-5-F-4-CHO-Pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoroisonicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, 1H/13C NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.