Description

4-Chloro-3-Fluoro-2-Methoxypyridine is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing halogen and methoxy substituents into complex molecular architectures, enabling precise structural modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyridine core.
• Material Science Research: Used in the synthesis of functionalized ligands for catalysis and advanced organic electronic materials.
• Chemical Biology Probes: Serves as a precursor for labeled compounds and molecular probes used in biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Methoxypyridine
CAS No.	1227572-96-4
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-Methoxy-4-chloro-3-fluoropyridine; 3-Fluoro-4-chloro-2-methoxypyridine; 4-Chloro-3-fluoro-2-pyridinol methyl ether; 4-Chloro-3-fluoro-2-methoxypyridine; Pyridine, 4-chloro-3-fluoro-2-methoxy-; 1227572-96-4
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoro-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.