Description

Ethyl 5-Fluoropyrimidine-2-Carboxylate is a high-purity fluorinated pyrimidine derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinases and other enzymes where the fluoropyrimidine moiety is critical for bioactivity and metabolic stability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom can enhance compound lipophilicity and target binding.
• Chemical Biology & Probe Development: Serves as a versatile handle for creating fluorescent probes or affinity labels to study biological systems and enzyme mechanisms.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials due to its conjugated pyrimidine ring system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in multi-step custom synthesis projects for clients.
• Academic & Institutional Research: Used in university and government laboratories for fundamental research in heterocyclic and fluorine chemistry.

Basic Information

Product Name	Ethyl 5-Fluoropyrimidine-2-Carboxylate
CAS No.	1227572-02-2
Molecular Formula	C7H7FN2O2
Molecular Weight	170.14 g/mol
Synonyms	5-Fluoropyrimidine-2-carboxylic acid ethyl ester; Ethyl 5-fluoropyrimidine-2-carboxylate; 2-Pyrimidinecarboxylic acid, 5-fluoro-, ethyl ester; 5-Fluoro-2-pyrimidinecarboxylic acid ethyl ester; Ethyl 5-fluoro-2-pyrimidinecarboxylate; 1227572-02-2; 5-Fluoropyrimidine-2-carboxylic acid, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 5-Fluoropyrimidine-2-Carboxylate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality commitment supports compliance in cGMP (current Good Manufacturing Practice) environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, we recommend maintaining the product at 2-8°C under an inert atmosphere to preserve stability and prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.