Description

2-Fluoro-5-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the nicotinic acid scaffold, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other functional materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up services for specialized chemical entities.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Nicotinic Acid
CAS No.	1227512-36-8
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	2-Fluoro-5-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Carboxy-2-fluoro-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-fluoronicotinic acid; Nicotinic acid, 2-fluoro-5-(trifluoromethyl)-; 2-Fluoro-5-trifluoromethylnicotinic acid
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated intermediates. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is analyzed to ensure it meets exacting purity standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with every shipment to ensure traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.