Description

3-Fluoro-4-Hydroxy-2-Methoxypyridine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring fluorine, hydroxyl, and methoxy groups on the pyridine ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant heterocycles.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal catalysis and organocatalysts due to its electron-donating and coordinating properties.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials where its specific polarity and hydrogen-bonding capability are advantageous.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Fluoro-4-Hydroxy-2-Methoxypyridine
CAS No.	1227511-87-6
Molecular Formula	C6H6FNO2
Molecular Weight	143.12 g/mol
Synonyms	2-Methoxy-3-fluoro-4-hydroxypyridine; 4-Hydroxy-3-fluoro-2-methoxypyridine; 3-Fluoro-2-methoxy-4-pyridinol; 3-Fluoro-4-pyridinol, 2-methoxy-; 2-Methoxy-3-fluoropyridin-4-ol; 3-Fluoro-4-hydroxy-2-methoxypyridine; 1227511-87-6 (CAS)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Hydroxy-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.