Description

2-Amino-4-(Trifluoromethyl)Nicotinic Acid is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of a nicotinic acid scaffold, an amino group, and a trifluoromethyl moiety, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a critical precursor for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and material science.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for advanced materials, such as organic semiconductors or liquid crystals.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	2-Amino-4-(Trifluoromethyl)Nicotinic Acid
CAS No.	1227489-68-0
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)pyridine-3-carboxylic acid; 4-(Trifluoromethyl)-2-aminonicotinic acid; 3-Pyridinecarboxylic acid, 2-amino-4-(trifluoromethyl)-; 2-Amino-4-trifluoromethylnicotinic acid; 2-Amino-4-trifluoromethyl-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-(Trifluoromethyl)Nicotinic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via techniques such as HPLC, NMR, and mass spectrometry is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.