Description

5-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (Saltdata: Free) is a high-purity, reactive sulfonyl chloride derivative, a critical building block in advanced organic synthesis. Its value lies in its role as a versatile electrophilic reagent for introducing the sulfonamide moiety, enabling the creation of compounds with tailored biological and physicochemical properties. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used to construct novel sulfonamide herbicides, fungicides, and plant growth regulators.
• Functional Material Development: Building block for creating specialty polymers, dyes, and photoactive materials requiring sulfonamide linkages.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules on laboratory to pilot scale.
• Academic & Industrial R&D: Serves as a fundamental reagent in medicinal chemistry and process chemistry research programs.

Basic Information

Product Name	5-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (Saltdata: Free)
CAS No.	1227465-58-8
Molecular Formula	C8H6ClNO4S
Molecular Weight	247.66 g/mol
Synonyms	6-(Chlorosulfonyl)-5-methyl-2-benzoxazolinone; 5-Methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride; 5-Methyl-2,3-dihydro-2-oxo-1,3-benzoxazole-6-sulfonyl chloride; 1,3-Benzoxazol-2(3H)-one, 6-(chlorosulfonyl)-5-methyl-; 5-Methyl-2-oxo-2H-1,3-benzoxazole-6-sulfonyl chloride; 5-Methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride (Free of salt)
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.