Description

Philanthotoxin 74 is a potent, non-competitive antagonist of ionotropic glutamate receptors, specifically targeting the kainate and AMPA subtypes. This compound is a crucial research tool in neuroscience for studying synaptic transmission, excitotoxicity, and neurological disorders. It is primarily utilized by pharmaceutical researchers, academic neuroscientists, and biotechnology companies engaged in neuropharmacology and drug discovery for conditions like epilepsy, stroke, and neurodegenerative diseases.

Application

• Neuroscience Research: A key pharmacological tool for investigating the function and role of kainate and AMPA receptors in central nervous system signaling.
• Drug Discovery Screening: Used in in vitro assays to identify and characterize novel compounds targeting ionotropic glutamate receptors for therapeutic potential.
• Mechanistic Studies: Facilitates studies on excitotoxicity, a process implicated in stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer's and Parkinson's.
• Electrophysiology: Employed in patch-clamp experiments to block specific glutamate receptor currents, allowing for the isolation and study of other synaptic components.
• Cellular Model Validation: Used to validate cellular and animal models of neurological disorders by modulating glutamatergic pathway activity.

Basic Information

Product Name	Philanthotoxin 74
CAS No.	1227301-51-0
Molecular Formula	C₂₀H₃₈N₈O₄
Molecular Weight	454.57 g/mol
Synonyms	PhTX-74; Philanthotoxin-74; 1,5-Bis[(4-aminophenyl)pent-1,4-dien-3-yl]pentane-1,5-diamine; Glutamate receptor antagonist PhTX-74; Non-competitive AMPA/kainate receptor antagonist
EINECS	Contact for details

Quality Control

Our Philanthotoxin 74 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.