Description

1-Bromo-4-(1-Trifluoromethyl-Cyclopropyl)-Benzene is a high-value, multi-functional aromatic building block featuring a unique combination of a bromo substituent and a trifluoromethylcyclopropyl group. This structure makes it an essential intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its halogen and fluorine moieties are critical for tuning electronic properties and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, where its aromatic and fluorinated structure contributes to desired dielectric and luminescent properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for versatile palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of the rigid, lipophilic trifluoromethylcyclopropyl group on molecular conformation and reactivity.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.

Basic Information

Product Name	1-Bromo-4-(1-Trifluoromethyl-Cyclopropyl)-Benzene
CAS No.	1227160-18-0
Molecular Formula	C10H8BrF3
Molecular Weight	265.07 g/mol
Synonyms	4-Bromo-α,α,α-trifluoro-1-cyclopropylbenzene; 1-Bromo-4-(trifluoromethylcyclopropyl)benzene; p-Bromo(trifluoromethylcyclopropyl)benzene; [1-Bromo-4-(1-trifluoromethylcyclopropyl)phenyl]; Benzene, 1-bromo-4-(1-(trifluoromethyl)cyclopropyl)-; (4-Bromophenyl)(trifluoromethyl)cyclopropane
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-4-(1-Trifluoromethyl-Cyclopropyl)-Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; handle and store under an inert atmosphere such as nitrogen for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.