Description

2-Bromo-4-Fluoro-3-Methoxy-1-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bromine and fluorine atoms for potent biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized as a backbone for creating novel phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Chemical Biology Probes: Acts as a starting material for synthesizing fluorinated probes and tags used in bioimaging and diagnostic applications.

Basic Information

Product Name	2-Bromo-4-Fluoro-3-Methoxy-1-Methylbenzene
CAS No.	1226808-62-3
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-Bromo-2-fluoro-5-methoxy-4-methylbenzene; 4-Bromo-5-fluoro-2-methoxytoluene; 2-Methoxy-5-methyl-4-fluorobromobenzene; 2-Bromo-4-fluoro-3-methoxytoluene; Benzene, 2-bromo-4-fluoro-3-methoxy-1-methyl-; Toluene, 4-bromo-5-fluoro-2-methoxy-
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-3-Methoxy-1-Methylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.