Description

(R,R,S,S)-Orlistat is a specific stereoisomer of the lipase inhibitor Orlistat, a compound of significant interest in pharmaceutical research and development. Its precise stereochemistry is critical for studying structure-activity relationships and developing novel therapeutic agents targeting lipid metabolism. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on metabolic disorders, anti-obesity drugs, and advanced synthetic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis and research of lipase inhibitors and related active pharmaceutical ingredients (APIs).
• Metabolic Disorder Research: Used in preclinical and clinical research to investigate the mechanisms of fat absorption and develop treatments for obesity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Employed in the development and optimization of stereoselective synthetic routes for complex organic molecules.
• Academic & Institutional Research: Utilized in universities and research institutes for biochemical studies on enzyme inhibition and metabolic pathways.

Basic Information

Item	Detail
Product Name	(R,R,S,S)-Orlistat
CAS No.	1225451-00-2
Molecular Formula	C29H53NO5
Molecular Weight	495.74 g/mol
Synonyms	(3S,4S)-3-Hexyl-4-[(2S)-2-hydroxytridecanoyl]oxy]-5-oxooxolane-2-carboxylic acid (1S)-1-[[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl]dodecyl ester; Tetrahydrolipstatin stereoisomer; Orlistat impurity; THL stereoisomer; Lipase inhibitor intermediate; (R,R,S,S)-Tetrahydrolipstatin
EINECS	Contact for details

Quality Control

Our (R,R,S,S)-Orlistat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis for stereochemical confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R,R,S,S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.