Description

1-Bromo-4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Benzene is a high-purity, specialty fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a reactive bromoarene group and a robust, electron-withdrawing trifluoromethyl-substituted tertiary-butyl moiety, enabling precise molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require sophisticated intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials, where its aromatic and fluorinated structure contributes to desired dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced chemical resistance, lower dielectric constants, and improved weatherability.
• Ligand & Catalyst Development: Functions as a scaffold for creating novel phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis for fine chemical production.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on cross-coupling reactions (e.g., Suzuki, Negishi) and exploring new fluorinated compound libraries.

Basic Information

Product Name	1-Bromo-4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Benzene
CAS No.	1225380-05-1
Molecular Formula	C11H10BrF3
Molecular Weight	279.10 g/mol
Synonyms	2-(4-Bromophenyl)-1,1,1-trifluoro-2-methylpropane; 4-Bromo-α,α,α-trifluoro-2,2-dimethyltoluene; p-Bromo(1,1,1-trifluoro-2-methyl-2-propyl)benzene; 1-Bromo-4-(2,2,2-trifluoro-1,1-dimethylethyl)benzene; (4-Bromophenyl)(tert-butyl)trifluoromethane; 2-(4-Bromophenyl)-2-methyl-1,1,1-trifluoropropane; 4-Bromo-α,α,α-trifluoro-2,2-dimethylpropylbenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.