Description

2,5-Dimethoxy-4-Methylbenzenesulfonyl Chloride (Saltdata: Free) is a specialized sulfonyl chloride derivative, a key building block in advanced organic synthesis. Its primary value lies in its high reactivity as a sulfonylation agent, enabling the precise introduction of the sulfonyl functional group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), intermediates, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of sulfonamide-based drug candidates, including potential antimicrobials, diuretics, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the sulfonyl moiety is a key pharmacophore.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized sulfonated dyes and colorants.
• Polymer Modification: Employed to introduce sulfonyl groups into polymer chains, altering material properties like solubility and thermal stability.
• Cross-coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	2,5-Dimethoxy-4-Methylbenzenesulfonyl Chloride (Saltdata: Free)
CAS No.	1225058-92-3
Molecular Formula	C9H11ClO4S
Molecular Weight	250.70 g/mol
Synonyms	4-Methyl-2,5-dimethoxybenzenesulfonyl chloride; 2,5-Dimethoxy-4-methylbenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-2,5-dimethoxy-4-methylbenzene; 4-Methyl-1,4-dimethoxybenzenesulfonyl chloride; 2,5-Dimethoxy-p-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,5-Dimethoxy-4-Methylbenzenesulfonyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.