Description

4,4-Difluoropiperidine-1-Sulfonyl Chloride is a high-value, multi-functional chemical building block featuring a reactive sulfonyl chloride group on a difluorinated piperidine scaffold. This compound matters for its critical role in medicinal chemistry as a key intermediate in the synthesis of novel pharmaceutical candidates, particularly in kinase inhibitor and protease inhibitor research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex sulfonamide derivatives.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and protease inhibitors.
• Agrochemical Research: Used in the development of novel herbicides and pesticides with enhanced biological activity and selectivity.
• Chemical Biology Probes: Serves as a reactive handle for labeling proteins or modifying biomolecules in probe development.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialty polymers with unique fluorinated properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D pipelines.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and fluorine chemistry.

Basic Information

Product Name	4,4-Difluoropiperidine-1-Sulfonyl Chloride
CAS No.	1224929-81-0
Molecular Formula	C5H8ClF2NO2S
Molecular Weight	219.64 g/mol
Synonyms	1-(Chlorosulfonyl)-4,4-difluoropiperidine; 4,4-Difluoropiperidine-1-sulfonyl chloride; 4,4-Difluoro-1-piperidinesulfonyl chloride; 4,4-Difluoropiperidine sulfonyl chloride; Piperidine, 4,4-difluoro-1-sulfonyl chloride; 1-Piperidinesulfonyl chloride, 4,4-difluoro-; 4,4-Difluoro-piperidine-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoropiperidine-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.