Description

Gsk-2256098 CAS NO 1224887-10-8 is a potent and selective small molecule inhibitor of protein kinase B (PKB/Akt), a key signaling node in the PI3K/Akt/mTOR pathway. This compound is crucial for researchers and developers targeting cancer, metabolic disorders, and other diseases driven by aberrant Akt signaling. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies for drug discovery, target validation, and biochemical pathway analysis.

Application

• Biomedical Research: A critical tool for studying the role of Akt isoforms in cellular processes such as proliferation, apoptosis, and metabolism.
• Oncology Drug Discovery: Used as a reference compound and a starting point for developing novel anti-cancer therapeutics targeting the PI3K/Akt pathway.
• Signal Transduction Studies: Enables precise inhibition of Akt to dissect its function in complex signaling networks and disease models.
• Preclinical Development: Serves as a pharmacological probe in animal models to evaluate the therapeutic potential of Akt inhibition.
• High-Throughput Screening (HTS): Employed as a control or standard in assays designed to identify new Akt inhibitors or modulators.
• Chemical Biology: Used to investigate the downstream effects of Akt inhibition on protein phosphorylation and cellular phenotype.

Basic Information

Product Name	Gsk-2256098
CAS No.	1224887-10-8
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	GSK2256098; GSK-6098; 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[(2R)-2-methyl-1-piperazinyl]methyl]thiophene-2-carboxamide; Akt inhibitor GSK2256098; FAK/Akt Dual Inhibitor; Protein Kinase B Inhibitor
EINECS	Contact for details

Quality Control

Our Gsk-2256098 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.