Description

[2H8]-Lopinavir CAS NO 1224729-35-4 is a deuterated isotopologue of the antiretroviral protease inhibitor Lopinavir, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and clinical research for HIV/AIDS treatments.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of Lopinavir in biological matrices (plasma, serum, tissues).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioequivalence Studies: Used in comparative studies to ensure generic formulations match the reference drug's performance.
• Therapeutic Drug Monitoring (TDM): Facilitates the precise monitoring of Lopinavir concentrations in patient samples to optimize dosing regimens and efficacy.
• Metabolite Identification: Aids in the structural elucidation of Lopinavir metabolites by providing a stable isotopic reference point.
• Pharmaceutical Quality Control: Supports method development and validation for the analysis of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	[2H8]-Lopinavir
CAS No.	1224729-35-4
Molecular Formula	C37H40D8N4O5
Molecular Weight	~ 636.85 g/mol
Synonyms	Lopinavir-d8; Deuterated Lopinavir (d8); LPV-d8; (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-2-hexanyl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide-d8; ABT-378-d8; 1-[(2S,4S,5S)-5-[[(2S)-3-Methyl-2-(2-oxoperhydro-1,3-diazin-1-yl)butanoyl]amino]-4-hydroxy-1,6-diphenyl-2-hexanyl]-3,3-dimethyl-2-(2,6-xylyloxy)butyramide-d8
EINECS	Contact for details

Quality Control

Our [2H8]-Lopinavir is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. Certificates of Analysis (COA) are provided, detailing purity, isotopic purity (deuterium incorporation), and analytical data. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.