Description

6-Bromo-3-Nitro-2-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. This compound is particularly significant for its trifluoromethyl and nitro substituents, which are key motifs for modulating the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for creating specialty chemicals, liquid crystals, and advanced polymers with unique electronic properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro group at the 3-position activates the molecule for substitution reactions, allowing for further functionalization.
• Fluorine Chemistry: An important reagent for introducing fluorine-containing motifs into molecules, a critical strategy in modern drug design to improve bioavailability and binding affinity.

Basic Information

Product Name	6-Bromo-3-Nitro-2-(Trifluoromethyl)Pyridine
CAS No.	1224321-68-9
Molecular Formula	C7H2BrF3N2O2
Molecular Weight	284.99 g/mol
Synonyms	2-Bromo-5-nitro-6-(trifluoromethyl)pyridine; 6-Bromo-3-nitro-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-6-bromo-3-nitropyridine; Pyridine, 6-bromo-3-nitro-2-(trifluoromethyl)-; 1224321-68-9
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-Nitro-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.