Description

2-(Bromomethyl)Benzal Fluoride, also known as 1-(Bromomethyl)-2-(Difluoromethyl)Benzene, is a versatile and highly reactive organofluorine building block. This compound is valued for its ability to introduce both bromomethyl and difluoromethyl functional groups into target molecules, enabling precise structural modifications in advanced synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl or benzyl-bromide motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoromethyl group can enhance efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with unique fluorinated properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.
• Fluorine Chemistry Exploration: An essential reagent for academic and industrial research focused on incorporating fluorine atoms into organic molecules to alter physical, chemical, and biological properties.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands and organocatalysts that leverage the electronic effects of the difluoromethyl group.

Basic Information

Item	Details
Product Name	2-(Bromomethyl)Benzal Fluoride / 1-(Bromomethyl)-2-(Difluoromethyl)Benzene
CAS No.	1222556-61-7
Molecular Formula	C9H7BrF2
Molecular Weight	233.05 g/mol
Synonyms	1-(Bromomethyl)-2-(difluoromethyl)benzene; 2-(Bromomethyl)-α,α-difluorotoluene; α-(Bromomethyl)-α,α-difluoro-o-xylene; o-(Bromomethyl)benzal fluoride; Benzene, 1-(bromomethyl)-2-(difluoromethyl)-; (2-(Bromomethyl)phenyl)difluoromethane
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)Benzal Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.