Description

Skepinone-L is a potent and selective inhibitor of p38α mitogen-activated protein kinase (MAPK), a key signaling protein involved in cellular stress and inflammatory responses. This compound is a critical research tool for elucidating the p38 MAPK pathway's role in disease models and for validating novel therapeutic targets. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and development for inflammatory and autoimmune conditions.

Application

• Biochemical Research: A selective tool compound for studying p38α MAPK signaling pathways in vitro.
• Drug Discovery: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for anti-inflammatory therapeutics.
• Cell Biology Studies: Employed to investigate the role of p38 MAPK in cellular processes like apoptosis, differentiation, and cytokine production.
• Preclinical Development: Serves as a key molecule in validating the efficacy of targeting p38α in animal models of inflammation and autoimmune diseases.

Basic Information

Product Name	Skepinone-L
CAS No.	1221485-83-1
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Skepinone-L; 6-(4-Fluorophenyl)-2-[3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-imidazo[4,5-b]pyridine; (S)-6-(4-Fluorophenyl)-2-(3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-imidazo[4,5-b]pyridine; p38α MAPK Inhibitor Skepinone-L; Selective p38α inhibitor
EINECS	Contact for details

Quality Control

Our Skepinone-L is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.