Description

5-Chloro-1,3-Difluoro-2-(Trifluoromethyl)Benzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its substitution pattern is leveraged to fine-tune biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing lipophilic and electron-withdrawing motifs that can enhance membrane permeability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated benzene core contributes to product efficacy and environmental persistence profiles.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic materials, contributing to desired dielectric and luminescent properties.
• Specialty Polymer Modifier: Incorporated into polymer backbones to impart specific characteristics such as chemical resistance, thermal stability, or altered refractive index.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to construct complex, functionalized aromatic systems.

Basic Information

Item	Detail
Product Name	5-Chloro-1,3-Difluoro-2-(Trifluoromethyl)Benzene
CAS No.	1221272-93-0
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	2-Chloro-4,6-difluoro-α,α,α-trifluorotoluene; 1-Chloro-3,5-difluoro-2-(trifluoromethyl)benzene; 5-Chloro-1,3-difluoro-2-(trifluoromethyl)benzene; Benzene, 5-chloro-1,3-difluoro-2-(trifluoromethyl)-; 2-Trifluoromethyl-5-chloro-1,3-difluorobenzene
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for our advanced intermediates. Production is supported by modern analytical techniques including GC, HPLC, and NMR for precise identification and quantification. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.