Description

1-(Bromomethyl)-4-(2,2,2-Trifluoroethyl)Benzene, also known as α-Bromo-4-(2,2,2-trifluoroethyl)toluene, is a versatile and high-purity organic building block. This compound is valued for its reactive benzyl bromide moiety and the electron-withdrawing trifluoroethyl group, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those incorporating trifluoroethyl aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl/ethyl group is a common active component.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of advanced electronic materials for displays and lighting, leveraging its aromatic and halogenated structure.
• Cross-Coupling Reactions: The benzyl bromide functionality makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Functionalized Polymer Monomer: Can be incorporated into polymer backbones to introduce specific properties like hydrophobicity or altered refractive index.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(Bromomethyl)-4-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1221272-87-2
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	α-Bromo-4-(2,2,2-trifluoroethyl)toluene; 4-(2,2,2-Trifluoroethyl)benzyl Bromide; 1-(Bromomethyl)-4-(2,2,2-trifluoroethyl)benzene; (4-(2,2,2-Trifluoroethyl)phenyl)methyl Bromide; α-Bromo-4-(trifluoroethyl)toluene; p-(Trifluoroethyl)benzyl Bromide; Benzene, 1-(bromomethyl)-4-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-4-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specification results. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.