Description

1-Chloro-3-(Difluoromethyl)-2,4-Difluorobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both chloro and difluoromethyl substituents on a difluorobenzene ring, makes it a critical intermediate for introducing specific fluorine patterns into target molecules. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for developing novel active ingredients, where its precise fluorination is key to modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for introducing lipophilic and metabolically stable motifs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where fluorine atoms enhance efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting materials, improving performance and stability.
• Polymer & Specialty Chemicals: Employed to create fluorinated monomers and additives that impart unique properties like oil/water repellency and chemical resistance to polymers.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl systems.
• Organic Synthesis & Chemical Research: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	1-Chloro-3-(Difluoromethyl)-2,4-Difluorobenzene
CAS No.	1221272-82-7
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	2,4-Difluoro-1-chloro-3-(difluoromethyl)benzene; 3-(Difluoromethyl)-2,4-difluorochlorobenzene; 1-Chloro-2,4-difluoro-3-(difluoromethyl)benzene; 2,4-Difluoro-α,α-difluoro-3-chlorotoluene; 3-Chloro-α,α,2,4-tetrafluorotoluene; Benzene, 1-chloro-3-(difluoromethyl)-2,4-difluoro-; CAS 1221272-82-7
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-(Difluoromethyl)-2,4-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames. Keep away from incompatible materials such as strong bases and reactive metals.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Density (at 20°C)	~1.5 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.