Description

1-Chloro-2-(Difluoromethyl)-3-Fluoro-4-Methylbenzene is a high-purity, multi-functional fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research institutions and industrial R&D teams in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry for creating molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl and fluoro groups contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials for OLEDs and other electronic devices.
• Advanced Polymer Chemistry: Acts as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and lowering surface energy.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex, fluorinated aromatic scaffolds in academic and industrial labs.

Basic Information

Item	Detail
Product Name	1-Chloro-2-(Difluoromethyl)-3-Fluoro-4-Methylbenzene
CAS No.	1221272-76-9
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	2-Chloro-α,α-difluoro-3-fluoro-p-xylene; 3-Fluoro-4-methyl-2-(difluoromethyl)chlorobenzene; 1-Chloro-2-(difluoromethyl)-3-fluoro-4-methyl-benzene; 2-(Difluoromethyl)-3-fluoro-4-methylchlorobenzene; Benzene, 1-chloro-2-(difluoromethyl)-3-fluoro-4-methyl-; 4-Methyl-2-(difluoromethyl)-3-fluorochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(Difluoromethyl)-3-Fluoro-4-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.