Description

2-Chloro-6-Trifluoromethoxy-Pyridin-4-Ylamine is a high-purity, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogenated and trifluoromethoxy-substituted structure makes it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging the bioactivity of the pyridine core and halogen substituents.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis and scale-up projects.

Basic Information

Product Name	2-Chloro-6-Trifluoromethoxy-Pyridin-4-Ylamine
CAS No.	1221171-99-8
Molecular Formula	C7H4ClF3N2O
Molecular Weight	212.57 g/mol
Synonyms	4-Amino-2-chloro-6-(trifluoromethoxy)pyridine; 2-Chloro-6-(trifluoromethoxy)pyridin-4-amine; 4-Pyridinamine, 2-chloro-6-(trifluoromethoxy)-; 2-Chloro-6-trifluoromethoxy-pyridin-4-ylamine; 2-Chloro-6-(trifluoromethoxy)-4-aminopyridine; 1221171-99-8; 4-Amino-2-chloro-6-(trifluoromethoxy)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Trifluoromethoxy-Pyridin-4-Ylamine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.