Description

2-(Trifluoromethoxy)Nicotinic Acid is a high-value fluorinated nicotinic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethoxy group and a carboxylic acid functionality, makes it indispensable for creating novel compounds with enhanced properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science: Building block for synthesizing advanced polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2-(Trifluoromethoxy)Nicotinic Acid
CAS No.	1221171-92-1
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-(Trifluoromethoxy)pyridine-3-carboxylic acid; Nicotinic acid, 2-(trifluoromethoxy)-; 3-Pyridinecarboxylic acid, 2-(trifluoromethoxy)-; 2-Trifluoromethoxynicotinic acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.