Description

3-(Trifluoromethoxy)Isonicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethoxy group and a carboxylic acid moiety on the pyridine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic properties.
• Chemical Biology Probes: Utilized as a building block for designing molecular probes and diagnostic agents.

Basic Information

Product Name	3-(Trifluoromethoxy)Isonicotinic Acid
CAS No.	1221171-76-1
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-(Trifluoromethoxy)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 3-(trifluoromethoxy)-; Isonicotinic acid, 3-(trifluoromethoxy)-; 3-Trifluoromethoxyisonicotinic acid; 3-(Trifluoromethoxy)-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.