Description

2-(4-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system. This compound is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its piperidine and trifluoromethylpyridine motifs.
• Process Chemistry & Scale-Up: Serves as a defined starting material for the development and validation of robust, scalable synthetic routes under GMP conditions.
• API Manufacturing: Incorporated into the final synthetic steps for producing target active pharmaceutical ingredients.
• Biochemical Tool Compound: Potential use in the development of probes for studying biological targets and pathways in academic and industrial R&D.
• Custom Synthesis: Basis for the preparation of more complex, proprietary analogs and derivatives for client-specific projects.

Basic Information

Product Name	2-(4-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride
CAS No.	1220036-99-6
Molecular Formula	C12H15F3N2O·HCl
Molecular Weight	295.72 g/mol
Synonyms	5-(Trifluoromethyl)-2-[(4-piperidinyl)methoxy]pyridine hydrochloride; 2-((Piperidin-4-yl)methoxy)-5-(trifluoromethyl)pyridine HCl; 2-(4-Piperidylmethoxy)-5-trifluoromethylpyridine hydrochloride; 2-Piperidin-4-ylmethoxy-5-trifluoromethyl-pyridine hydrochloride; 1220036-99-6; 5-(Trifluoromethyl)-2-(piperidin-4-ylmethoxy)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(4-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.