Description

Methylphenidate-D9 is a stable isotope-labeled analog of the central nervous system stimulant methylphenidate, where nine hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for applications requiring precise internal standardization.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of methylphenidate and its metabolites in biological matrices.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in method development and validation for the definitive identification and measurement of methylphenidate in urine, blood, or plasma samples.
• Pharmaceutical Quality Control: Supports assay development and impurity profiling for drug substance and finished product testing in GMP environments.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy IDMS techniques, which are considered a primary method of measurement.
• Research on Drug Delivery Systems: Aids in the study of novel formulation efficacy by providing a distinguishable tracer from the native compound.

Basic Information

Item	Details
Product Name	Methylphenidate-D9
CAS No.	1219908-85-6
Molecular Formula	C₁₄H₁₀D₉NO₂
Molecular Weight	243.35 g/mol (approx.)
Synonyms	Methylphenidate-d9; dl-Methylphenidate-d9; (±)-Methylphenidate-d9; Methylphenidate (phenyl-d5, piperidine-d4); α-Phenyl-2-piperidineacetic acid methyl ester-d9; Ritalin-d9; Deuterated Methylphenidate; Methylphenidate Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Methylphenidate-D9 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail isotopic purity (typically >98% deuterium incorporation), chemical purity (by HPLC), and confirm structural identity. Our quality commitment ensures the material meets the stringent requirements for analytical reference standards used in regulated laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.