Description

Rsl3 (CAS NO 1219810-16-8) is a potent and selective small molecule inhibitor targeting key cellular pathways involved in ferroptosis, a form of regulated cell death. This compound is of significant value for research and development in oncology and neurodegenerative disease studies, providing a critical tool for modulating oxidative stress responses. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on drug discovery and mechanistic biology.

Application

• Research tool for studying the mechanisms of ferroptosis and oxidative stress in cellular models.
• Preclinical investigation of potential therapeutic agents for cancer treatment.
• Biochemical research to understand the role of GPX4 and related pathways in disease pathology.
• High-throughput screening campaigns to identify novel compounds that interact with ferroptosis pathways.
• Use as a reference standard in analytical method development for pharmacokinetic studies.
• Investigation of neuroprotective strategies in models of neurodegenerative conditions like Parkinson's and Alzheimer's disease.

Basic Information

Product Name	Rsl3
CAS No.	1219810-16-8
Molecular Formula	C17H14F3N3O2S
Molecular Weight	405.37 g/mol
Synonyms	(1S,3R)-RSL3; RSL 3; RSL-3; MLS-0315771; (1S,3R)-RSL-3; (1S,3R)-2-(2-Chloroacetyl)-1-(3,3-dimethylbutyl)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-2,3-dihydro-1H-indole-3-carboxamide; Ferroptosis Activator RSL3; GPX4 Inhibitor RSL3
EINECS	Contact for details

Quality Control

Our Rsl3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.