Description

4-Iodo Suberoylanilide Hydroxamic Acid is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes, specifically designed for advanced biochemical research. This compound matters for its critical role in epigenetic modulation, enabling the study of gene expression, cell cycle progression, and differentiation in various disease models. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and inflammatory disease research.

Application

• Biochemical Research: Used as a selective HDAC inhibitor to study epigenetic mechanisms and chromatin remodeling.
• Pharmaceutical Development: Serves as a key reference standard and pharmacologically active compound (PAC) in drug discovery pipelines for cancer and neurological disorders.
• Cell Biology Studies: Applied in *in vitro* assays to investigate the effects of HDAC inhibition on cell proliferation, apoptosis, and differentiation.
• Proteomics & Target Validation: Utilized in activity-based protein profiling (ABPP) and enzyme kinetic studies to validate HDAC isoforms as therapeutic targets.
• Academic Research: A vital tool for universities and research institutes exploring novel signaling pathways and therapeutic interventions.

Basic Information

Product Name	4-Iodo Suberoylanilide Hydroxamic Acid
CAS No.	1219807-87-0
Molecular Formula	C14H19IN2O3
Molecular Weight	414.22 g/mol
Synonyms	4-Iodo-SAHA; 4-Iodo-Vorinostat; 4-Iodo-N-Hydroxy-8-[4-(iodophenyl)carbamoyl]octanamide; 4-Iodo-Suberoyl Hydroxamic Acid Anilide; 4-Iodo-Suberanilohydroxamic Acid; 4-Iodo-SBHA; HDAC Inhibitor VIII (4-Iodo); (E)-N-Hydroxy-8-(4-iodophenylamino)-8-oxooct-6-enamide
EINECS	Contact for details

Quality Control

Our 4-Iodo Suberoylanilide Hydroxamic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and potency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with an appropriate desiccant in a freezer. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.