Description

n-Nitrosomorpholine-D8 is a stable isotope-labeled analog of n-nitrosomorpholine, where eight hydrogen atoms are replaced by deuterium. This compound is of critical importance as a high-purity internal standard and reference material for precise analytical quantification, particularly in mass spectrometry. It is essential for researchers and quality control laboratories in the pharmaceutical, environmental testing, and food safety sectors who require accurate trace analysis of nitrosamine impurities.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the accurate quantification of n-nitrosomorpholine and related nitrosamines in complex matrices.
• Pharmaceutical Impurity Testing: Used in method development and validation for monitoring and controlling genotoxic nitrosamine impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products to comply with regulatory guidelines (e.g., FDA, EMA).
• Environmental and Food Safety Analysis: Enables sensitive detection and measurement of nitrosamine contaminants in water, air, and food products like cured meats.
• Metabolic and Pharmacokinetic Studies: Serves as a tracer in advanced research to study the absorption, distribution, metabolism, and excretion (ADME) of nitrosomorpholine.
• Analytical Method Development: A critical tool for developing, optimizing, and calibrating highly sensitive analytical methods, including GC-MS and HPLC-MS.
• Quality Assurance & Control: Provides a benchmark for ensuring the accuracy and reliability of analytical results in contract research organizations (CROs) and quality control labs.

Basic Information

Product Name	n-Nitrosomorpholine-D8
CAS No.	1219805-76-1
Molecular Formula	C4D8N2O2
Molecular Weight	136.18 g/mol
Synonyms	Perdeuterated N-Nitrosomorpholine; Morpholine-D8, N-nitroso-; N-Nitrosomorpholine-d8; 2H,5H-Tetrahydro-1,4-oxazine-D8, 4-nitroso-; Deuterated Nitrosomorpholine; Nitrosomorpholine-d8; Isotope Labeled Nitrosomorpholine; Internal Standard for Nitrosomorpholine
EINECS	Contact for details

Quality Control

Our n-Nitrosomorpholine-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is thoroughly characterized using advanced techniques including NMR (Nuclear Magnetic Resonance) and Mass Spectrometry to confirm deuteration level and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or Certificate of Analysis. Due to its light-sensitive nature and high volatility, minimize exposure to ambient conditions and handle in a well-ventilated area.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.