Description

Mianserin-D3 Dihydrochloride is a deuterated, high-purity chemical reference standard, specifically the dihydrochloride salt of a labeled analog of the tetracyclic antidepressant mianserin. This compound is critical for ensuring the accuracy and reliability of quantitative analytical methods in pharmaceutical research and development. It is primarily required by analytical laboratories, CROs, and pharmaceutical companies engaged in method development, validation, and bioanalytical studies for pharmacokinetics and metabolism research.

Application

• Primary use as an Internal Standard (IS) for the quantification of mianserin in complex biological matrices using LC-MS/MS and GC-MS.
• Essential for conducting Deuterium Isotope Effect Studies to investigate metabolic pathways and stability of pharmaceutical compounds.
• Critical component in Bioanalytical Method Development and Validation for clinical and preclinical trials.
• Used in Pharmacokinetic (PK) and Pharmacodynamic (PD) Research to ensure precise measurement of drug concentration over time.
• Application in Drug Metabolism and Disposition Studies to trace and quantify metabolites.
• Serves as a certified reference material for Quality Control (QC) and assurance in analytical testing laboratories.

Basic Information

Product Name	Mianserin-D3 Dihydrochloride
CAS No.	1219804-97-3
Molecular Formula	C18H19D3N2•2HCl
Molecular Weight	338.33 g/mol (for free base C18H19D3N2)
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine-2,3,3-d3 Dihydrochloride; Mianserin-d3 Dihydrochloride; Deuterated Mianserin Dihydrochloride; Mianserin (phenyl-d3) Dihydrochloride; Tetramethylpyrazinylazepine-d3 Dihydrochloride; 6-Azathiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-d3 Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Mianserin-D3 Dihydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and all specification results is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.