Description

(±)-Metoprolol-D7 HCl is a deuterated internal standard of the widely used β-blocker, metoprolol, specifically labeled with seven deuterium atoms. This compound is essential for ensuring accuracy and reliability in quantitative bioanalytical methods, particularly liquid chromatography-mass spectrometry (LC-MS/MS). Pharmaceutical research and development laboratories, contract research organizations (CROs), and forensic toxicology facilities require this high-purity standard for precise pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of metoprolol and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion profiles.
• Drug Metabolism and Disposition Research: Used in studies investigating metabolic pathways, enzyme kinetics, and the formation of active or toxic metabolites.
• Clinical Trial Support: Provides reliable data for bioequivalence studies and therapeutic drug monitoring during clinical development phases.
• Forensic and Clinical Toxicology: Assists in the confirmatory analysis and quantification of metoprolol in cases of overdose or compliance monitoring.
• Method Development and Validation: A key component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.

Basic Information

Product Name	(±)-Metoprolol-D7 HCl
CAS No.	1219798-61-4
Molecular Formula	C15H18D7NO3 • HCl
Molecular Weight	~ 312.86 g/mol
Synonyms	Metoprolol-d7 Hydrochloride; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol-d7 Hydrochloride; DL-Metoprolol-d7 HCl; (±)-1'-[4-(2-Methoxyethyl)phenoxy]-3'-(isopropylamino)-2'-propanol-d7 Hydrochloride; Lopressor-d7 HCl; Toprol-XL-d7 HCl; Betaloc-d7 HCl; Metoprolol (D7) HCl
EINECS	Contact for details

Quality Control

Every batch of (±)-Metoprolol-D7 HCl is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, ensuring compliance with the stringent requirements of analytical reference standard applications. Our quality commitment supports method validation per ICH Q2(R1) and FDA bioanalytical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (MS)	≥98.0 atom % D
Isotopic Enrichment	≥99.0% D7 (by MS)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.