Description

Ampk Activator 991 CAS NO 1219739-95-3 is a potent and selective small molecule activator of the AMP-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis. This compound is a critical research tool for studying metabolic pathways, cellular stress responses, and the therapeutic potential of AMPK activation in various disease models. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on metabolic disorders, aging, and oncology.

Application

• Biomedical Research: A key pharmacological tool for in vitro and in vivo studies investigating the role of AMPK signaling in metabolism, autophagy, and cell growth.
• Drug Discovery & Development: Used as a reference compound and positive control in high-throughput screening (HTS) campaigns and lead optimization for metabolic disease targets.
• Metabolic Disease Studies: Facilitates research into Type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) by modulating glucose uptake and lipid metabolism.
• Oncology Research: Employed to study AMPK's tumor-suppressive functions and its interplay with pathways like mTOR in cancer cell proliferation and survival.
• Cardiovascular Research: Investigated for its potential protective effects in models of cardiac ischemia-reperfusion injury and heart failure.
• Neurological Research: Used to explore AMPK's neuroprotective roles in conditions such as Alzheimer's disease and Parkinson's disease.
• Anti-aging & Longevity Research: A compound of interest in studying cellular senescence, mitochondrial biogenesis, and lifespan extension pathways.

Basic Information

Product Name	Ampk Activator 991
CAS No.	1219739-95-3
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	AMPK Activator 991; 991; 4-Hydroxy-2-(1H-indol-5-yl)-6-phenylpyrimidine-5-carbonitrile; 6-Phenyl-4-hydroxy-2-(1H-indol-5-yl)pyrimidine-5-carbonitrile; 5-Cyano-6-phenyl-2-(1H-indol-5-yl)pyrimidin-4-ol; AMPK activator; AMPK agonist
EINECS	Contact for details

Quality Control

Our Ampk Activator 991 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool, and well-ventilated place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.