Description

3-Hydroxy Anagrelide-13C3 is a stable isotope-labeled analog of the active metabolite of the pharmaceutical agent Anagrelide. This compound is essential for conducting precise and reliable quantitative bioanalytical studies, particularly in pharmacokinetic and metabolism research. It serves as a critical internal standard in mass spectrometry-based assays, ensuring accurate measurement of drug and metabolite levels in biological matrices. This material is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug development and regulatory compliance.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Anagrelide and its metabolites in biological samples.
• Critical for conducting pharmacokinetic (PK) and bioavailability studies during drug development and clinical trials.
• Enables accurate drug metabolism and disposition (DMPK) research to understand the biotransformation pathways of Anagrelide.
• Supports bioanalytical method development and validation for regulatory submissions to agencies like the FDA and EMA.
• Facilitates therapeutic drug monitoring (TDM) research and assay development.
• Employed in isotope dilution analysis to achieve high precision and accuracy in complex sample matrices.

Basic Information

Product Name	3-Hydroxy Anagrelide-13C3
CAS No.	1219393-12-0
Molecular Formula	C10H713C3N3O2
Molecular Weight	~284.24 g/mol (for 13C3 labeled form)
Synonyms	6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one-13C3; Anagrelide Hydroxy Metabolite-13C3; 3-Hydroxyanagrelide-13C3; BCH-4556 Metabolite-13C3; [13C3]-3-Hydroxy Anagrelide; 6,7-Dichloro-1,5-dihydro-2H-imidazo[2,1-b]quinazolin-2-one-13C3; Isotopically Labeled Anagrelide Metabolite
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy Anagrelide-13C3 is manufactured and analyzed under strict quality systems. The product undergoes comprehensive testing to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques including HPLC, NMR, and Mass Spectrometry. Our quality commitment aligns with the standards expected for reference standards and critical reagents used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
13C Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.