Description

Choline Chloride-1-13C is a stable isotope-labeled analog of the essential nutrient choline chloride, where the carbon at the 1-position is the 13C isotope. This compound is a critical tool for advanced metabolic and pharmacokinetic research, enabling precise tracking and quantification in biological systems. It is primarily required by research institutions, pharmaceutical companies, and diagnostic manufacturers for use in tracer studies, mass spectrometry-based assays, and the development of internal standards.

Application

• Biomedical Tracer Studies: Used in metabolic pathway analysis to track choline utilization in lipid metabolism, neurotransmitter synthesis, and one-carbon metabolism.
• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the accurate quantification of choline and its metabolites (e.g., betaine, phosphatidylcholine) in complex biological matrices like plasma, tissue, and cell lysates.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in pharmaceutical research to study the absorption, distribution, metabolism, and excretion (ADME) of choline-based drug candidates.
• Nutritional Science Research: Facilitates studies on choline bioavailability, requirements, and functional outcomes in animal and human models.
• Diagnostic Assay Development: Used in the calibration and validation of clinical diagnostic kits for measuring choline-related biomarkers.
• NMR Spectroscopy: Acts as a 13C-enriched substrate for nuclear magnetic resonance (NMR) studies to elucidate molecular structures and dynamics.

Basic Information

Product Name	Choline Chloride-1-13C
CAS No.	1219388-71-2
Molecular Formula	C413CH14ClNO
Molecular Weight	140.61 g/mol (for 13C1 isotopologue)
Synonyms	(2-Hydroxyethyl)trimethylammonium-1-13C chloride; (β-Hydroxyethyl)trimethylammonium-1-13C chloride; 2-Hydroxy-N,N,N-trimethylethanaminium-1-13C chloride; Biocolina-1-13C; Hepacholine-1-13C; Lipotril-1-13C; 13C1-Choline chloride; 1-13C-Choline chloride
EINECS	Contact for details

Quality Control

Every batch of our Choline Chloride-1-13C is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic enrichment (Atom % 13C), chemical purity, and confirm identity. Our quality commitment aligns with the standards required for analytical reference materials and cGMP for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at 1-position
Chemical Purity (Titration)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.